PCT/US2014/041809

DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS

Details for PCT/US2014/041809

Application No.

PCT Application Number

PCT/US/2014/041809

Publication No.

PCT Publication Number

WO/2014/204729

Applicants

PCT Patent Applicants

THE BROAD INSTITUTE INC.
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
ZHANG, Feng
CONG, Le
RAN, Fei
HEIDENREICH, Matthias
SWIECH, Lukasz

Agents

PCT Patent Agents

KOWALSKI, Thomas, J. et al.

Priority Data

PCT Patent Priority Data

US61/979,879 filed on April 15, 2014
US61/871,301 filed on August 28, 2013
US61/862,355 filed on August 5, 2013
USPCT/US2013/074667 filed on December 12, 2013
US61/847,537 filed on July 17, 2013
US61/915,225 filed on December 12, 2013
US61/836,123 filed on June 17, 2013

PCT Pamphlet

The front page of the PCT Patent Application

PCT Pamphlet Front Page

Dates

Application Date

June 11, 2014

Publication Date

December 24, 2014

Earliest Priority Date

June 17, 2013

Deadlines

30 Month Date

30 Month National Phase Deadline.

December 17, 2015

31 Month Date

31 Month National Phase Deadline.

January 17, 2016

These dates are in the Past. Contact us to find out if National Phase entry is still possible.

Abstract

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Info

PCT Patent application PCT/US2014/041809 was filed on June 11, 2014 by THE BROAD INSTITUTE INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; ZHANG, Feng; CONG, Le; RAN, Fei; HEIDENREICH, Matthias; SWIECH, Lukasz. The title of this PCT Patent Application is "DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS" and the patent specification was published as WO/2014/204729 on December 24, 2014.

The earliest priority date for the patent application is June 17, 2013 and therefore the 30 month national phase deadline for PCT/US/2014/041809 is December 17, 2015 and the 31 month national phase deadline for PCT/US/2014/041809 is January 17, 2016

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